The entourage effect improves the efficacy of medicinal cannabis products.
More than the sum of the individual active ingredients
The synergistic effect of cannabinoids and terpenes is known as the entourage effect. The entourage effect is the synergistic interaction of all cannabinoids and terpenes. Only then does the full efficacy potential of a medicinal cannabis product reveal itself.
The cannabis flower contains 104 cannabinoids and more than 200 terpenes. Pain-relieving, anti-inflammatory and relaxing properties are important in an active ingredient for pain reduction. The cannabis flower combines these properties in its various ingredients. The cannabinoid THC has an analgesic and relaxing effect, CBD is anti-inflammatory and relaxing, cannabigerol (CBG) is, among other things, a muscle relaxant and anti-inflammatory, tetrahydrocannabivarin (THCV) exhibits an anticonvulsant effect, as does cannabidivarin (CBDV), and cannabicerol (CBC) has an anti-inflammatory and slight analgesic effect. The terpene β-myrcene inhibits inflammation and relaxes the muscles.
The problem of solubility
This synergistic effect is only provided by a liquid active ingredient that contains all cannabinoids and terpenes. A mono active ingredient such as dronabinol or a cannabis extract cannot do this. Even the so-called full-spectrum extracts do not contain all cannabinoids and terpenes of the cannabis flower, since an extracting agent can only dissolve those components of the cannabis flower that dissolve in it. There is no extracting agent that can dissolve all cannabinoids and terpenes with their different solubility properties.
PuranoTec changes that
The PuranoTec manufacturing technology crushes the entire cannabis flower down to the nanometer range and encases the water-insoluble cannabinoids and terpenes in the core of the nano-carrier, where they are completely dissolved. The smaller the water-insoluble components of the cannabis flower, the higher the solubility pressure, and thus the cannabinoids and terpenes in the special nano-carrier core dissolve more easily. Only dissolved cannabinoids and terpenes can have an effect in the body.